Effect Of Acute Gamma Irradiation On The Behavioral Parameters In White Mice

Authors

  • S.L. Kalmakhelidze Laboratory of Neurotoxicology, I.Beritashvili Center of Experimental Biomedicine, Georgia ; 2Department of Medical Physics and Biophysics, Tbilisi State Medical University, Georgia
  • D.P. Museridze Laboratory of Neurotoxicology, I. Beritashvili Center of Experimental Biomedicine, Georgia
  • T.V. Sanikidze Department of Medical Physics and Biophysics, Tbilisi State Medical University, Georgia

Keywords:

Gamma Irradiation, White Mice Behavior, Open Field Test

Abstract

High doses of ionizing radiation exposure have been shown to induce impairments in the limbic system. As hippocampal abnormalities have been linked to an impairment of behavioral functions, the present work aimed to investigate whether exposure to 5Gy of ionizing radiation can develop behavioral deficits in adult mice. White mice (Mus musculus) were irradiated with 137Cs. Experimental animals were tested in an open field maze over a period of 30 days after irradiation. A study of open-field parameters revealed that gamma irradiation can be considered a radiobiological factor inducing anxiety and emotionality in mice.

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Published

2023-02-22

How to Cite

Kalmakhelidze, S., Museridze, D., & Sanikidze, T. (2023). Effect Of Acute Gamma Irradiation On The Behavioral Parameters In White Mice. Radiobiology and Radiation Safety, 3(4), 45–50. Retrieved from https://radiobiology.ge/index.php/rrs/article/view/6292

Issue

Vol. 3 No. 4 (2023)

Section

Articles