IMPACT OF GAMMA IRRRADIATION ON THE THERMODYNAMIC AND METAL BINDING PROPERTIES OF BOVIN SERUM ALBUMIN

Authors

  • Tinatin Dolidze Iv. Beritashvili Canter of Experimental Biomedicine
  • Maia Makharadze Iv. Beritashvili Center of Experimental Biomedicine
  • Sophio Uchaneishvili Iv. Beritashvili Center of Experimental Biomedicine
  • Nazi Ivanishvili Iv. Beritashvili Center of Experimental Biomedicine
  • Mikheil Gogebashvili Iv. Beritashvili Canter of Experimental Biomedicine
  • David Vashakidze Iv. Beritashvili Canter of Experimental Biomedicine; Iv. Javakhishvili Tbilisi State University
  • Dimitri Khoshtariya Iv. Beritashvili Canter of Experimental Biomedicine; Iv. Javakhishvili Tbilisi State University

DOI:

https://doi.org/10.63465/rrs520258978

Keywords:

irradiation, bovin serum albumin, double charged copper ions, differential scanning calorimetry

Abstract

Effect of gamma(γ)- irradiation on the bovin serum albumin’s (BSA) global   thermodynamic stability and metal binding ability has been examined. 137Cs was used as a source of γ-irradiation. It has been shown that irradiation of BSA solution with doses 50Gy and 100Gy causes drastic decrease of amount of proteins molecules capable to interact and form complexes with double charged copper ions while the global stability of BSA is in less extent effected under the same irradiation conditions.

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Published

2025-04-28

How to Cite

Dolidze, T., Makharadze, M., Uchaneishvili, S., Ivanishvili, N., Gogebashvili, M., Vashakidze, D., & Khoshtariya, D. (2025). IMPACT OF GAMMA IRRRADIATION ON THE THERMODYNAMIC AND METAL BINDING PROPERTIES OF BOVIN SERUM ALBUMIN . Radiobiology and Radiation Safety, 5(6), 31–39. https://doi.org/10.63465/rrs520258978

Issue

Vol. 5 No. 6 (2025)

Section

Articles